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31 Machine Learning Algorithm to Predict Duration to Full Time Care after Alzheimer's Disease Diagnosis
- Jessica H Helphrey, Jayme M Palka, Jake Rossmango, Hudaisa Fatima, Michael Conley, Anthony Longoria, Jennifer Sawyer, Jeffrey Schaffert, Anne Carlew, Munro Cullum, Laura Lacritz, John Hart, Hsueh-Sheng Chiang, Trung Nguyen, Alka Khera, Christian LoBue
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- Journal:
- Journal of the International Neuropsychological Society / Volume 29 / Issue s1 / November 2023
- Published online by Cambridge University Press:
- 21 December 2023, p. 241
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Objective:
Patients and their families often ask clinicians to estimate when full-time care (FTC) will be needed after Alzheimer's Disease (AD) is diagnosed. Although a few algorithms predictive algorithms for duration to FTC have been created, these have not been widely adopted for clinical use due to questions regarding precision from limited sample sizes and lack of an easy, user friendly prediction model. Our objective was to develop a clinically relevant, data-driven predictive model using machine learning to estimate time to FTC in AD based on information gathered from a) clinical interview alone, and b) clinical interview plus neuropsychological data.
Participants and Methods:The National Alzheimer's Coordinating Center dataset was used to examine 3,809 participants (M age at AD diagnosis = 76.05, SD = 9.76; 47.10% male; 87.20% Caucasian) with AD dementia who were aged >50 years, had no history of stroke, and not dependent on others for basic activities of daily living at time of diagnosis based on qualitative self or informant report. To develop a predictive model for time until FTC, supervised machine learning algorithms (e.g., gradient descent, gradient boosting) were implemented. In Model 1, 29 variables captured at the time of AD diagnosis and often gathered in a clinical interview, including sociodemographic factors, psychiatric conditions, medical history, and MMSE, were included. In Model 2, additional neuropsychological variables assessing episodic memory, language, attention, executive function, and processing speed were added. To train and test the algorithm(s), data were split into a 70:30 ratio. Prediction optimization was examined via cross validation using 1000 bootstrapped samples. Model evaluation included assessment of confusion matrices and calculation of accuracy and precision.
Results:The average time to requiring FTC after AD diagnosis was 3.32 years (Range = 0.53-14.57 years). For the clinical interview only model (Model 1), younger age of onset, use of cholinesterase inhibitor medication, incontinence, and apathy were among the clinical variables that significantly predicted duration to FTC, with the largest effects shown for living alone, a positive family history of dementia, and lower MMSE score. In Model 2, the clinical predictors remained significant, and lower Boston Naming Test and Digit-Symbol Coding scores showed the largest effects in predicting duration to FTC among the neuropsychological measures. Final prediction models were further tested using five randomly selected cases. The average estimated time to FTC using the clinical interview model was within an average of 5.2 months of the recorded event and within an average of 5.8 months for the model with neuropsychological data.
Conclusions:Predicting when individuals diagnosed with AD will need FTC is important as the transition often carries significant financial costs related to caregiving. Duration to FTC was predicted by clinical and neuropsychological variables that are easily obtained during standard dementia evaluations. Implementation of the model for prediction of FTC in cases showed encouraging prognostic accuracy. The two models show promise as a first step towards creation of a user friendly prediction calculator that could help clinicians better counsel patients on when FTC after AD diagnosis may occur, though the development of separate models for use in more diverse populations will be essential.
355 Unraveling and targeting the innate immune response in Multisystem Inflammatory Syndrome in Children (MIS-C)
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- Jenna K Dick, Venkat Krishna, Aaron Khaimraj, Jianming Wu, Alberto Orioles, Maxim Cheeran, Jeffrey S. Miller, Marie Steiner, Geoffrey T. Hart
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- Journal:
- Journal of Clinical and Translational Science / Volume 7 / Issue s1 / April 2023
- Published online by Cambridge University Press:
- 24 April 2023, p. 105
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OBJECTIVES/GOALS: The innate immune responses to Multisystem Inflammatory Syndrome in Children (MIS-C) are not fully known. Using samples from MIS-C, we will assess the cellular responses and develop a novel Tri-Specific Killer Engager (TRiKE) that engages innate immune cells to improve those responses. METHODS/STUDY POPULATION: We collected blood samples from 60 pediatric patients from which we isolated plasma and peripheral blood mononuclear cells. We received blood samples from 13 MIS-C, 32 severe acute COVID, 5 COVID-19 asymptomatic, and 15 COVID-19 negative patients. Using plasma, we then performed ELISAs to determine IgG antibody levels against SARS-CoV-2 and plaque reduction neutralization tests to determine neutralizing antibody functions. We isolated DNA to look at Fc receptor genetics. We also utilized utilize flow cytometry assays determine the phagocytosis and killing abilities of the innate cells from these patients. This data will be correlated with clinical outcomes. Additionally, we have developed a novel SARS-CoV-2 TRiKE which directs natural killer (NK) cell killing specifically to of COVID-19 infected cells. RESULTS/ANTICIPATED RESULTS: MIS-C patients had higher IgG antibody titers against SARS-CoV-2 compared to children with symptomatic or asymptomatic COVID. MIS-C patients also neutralized SARS-CoV-2 more effectively than children with acute symptomatic or asymptomatic COVID-19. We found natural killer cells and monocytes are dysfunctional in MIS-C patients and do not kill SARS-CoV-2 infected cells as well. Specifically, NK cells do not kill COVID-19 infected cells as well. To combat this, we have successfully generated and are now testing a Tri-Specific Killer engager (TRiKE) which binds one ends to NK cells, one end to the Spike protein on COVID-19 infected cells and contains IL-15 to improve NK cell function. We anticipate that we can improve NK cell killing of COVID-19 infected cells with this TRiKE. DISCUSSION/SIGNIFICANCE: We found that MIS-C patients have antibodies that can neutralize SARS-CoV-2 but that that innate immune cells that engage antibodies are dysfunctional. We are have successfully developed and are targeting this response with a TRiKE to improve innate immune cell functional; this may serve as an adjunctive therapeutic if proven successful.
Exploring the demography and conservation needs of hawksbill sea turtles Eretmochelys imbricata in north-west Mexico
- Lourdes Martínez-Estévez, Abelino Angulo Angulo, Mayra Estrella Astorga, Cosme Damián Becerra, Nazario Campaña Leyva, Felipe Cuevas Amador, Juan Pablo Cuevas Amador, Tania de la Vega Carvajal, Anely Fernández Robledo, Alexander R. Gaos, Catherine E. Hart, Amy Hudson Weaver, José Luis López, Jesus Lucero, Israel Llamas, Agnese Mancini, Karen Oceguera, Jeffrey A. Seminoff, Bernie R. Tershy, Ingrid L. Yañez, Alan Zavala-Norzagaray, Donald A. Croll
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The hawksbill sea turtle Eretmochelys imbricata is categorized as Critically Endangered on the IUCN Red List and its population has declined by over 80% in the last century. The Eastern Pacific population is one of the most threatened hawksbill populations globally. Western Mexico is the northern distribution limit for hawksbill sea turtles in the Eastern Pacific and recent research indicates that the Mexican Pacific portion of the population is a separate management unit because of the restricted movements of these turtles. Here we use the most complete database of sighting records in the north-west Pacific of Mexico to identify sites where hawksbill turtles are present. We also develop a conservation index to determine the conservation status of hawksbill turtle sites. Our results demonstrate the importance of this region for juveniles and the relevance of rocky reefs and mangrove estuaries as habitats for hawksbill turtles. We identified 52 sites with records of hawksbill turtles. Most of these sites (71%) are not protected; however, sites with high conservation value included islands and coastal sites along the Baja California peninsula that are established as marine protected areas. Reefs and mangrove estuaries relevant for hawksbill turtles are probably also significant fish nursery areas that are important for local fishing communities, creating opportunities for conservation strategies that combine science, local engagement and policy to benefit both local fishing communities and hawksbill sea turtle conservation.
Implementation of a 24-hour infection diagnosis protocol in the pediatric cardiac intensive care unit (CICU)
- Reema A. Chitalia, Alexis L. Benscoter, Meghan M. Chlebowski, Kelsey J Hart, Ilias Iliopoulos, Andrew M. Misfeldt, Jaclyn E. Sawyer, Jeffrey A. Alten
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- Journal:
- Infection Control & Hospital Epidemiology / Volume 44 / Issue 8 / August 2023
- Published online by Cambridge University Press:
- 16 November 2022, pp. 1300-1307
- Print publication:
- August 2023
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Objectives:
To reduce unnecessary antibiotic exposure in a pediatric cardiac intensive care unit (CICU).
Design:Single-center, quality improvement initiative. Monthly antibiotic utilization rates were compared between 12-month baseline and 18-month intervention periods.
Setting:A 25-bed pediatric CICU.
Patients:Clinically stable patients undergoing infection diagnosis were included. Patients with immunodeficiency, mechanical circulatory support, open sternum, and recent culture-positive infection were excluded.
Interventions:The key drivers for improvement were standardizing the infection diagnosis process, order-set creation, limitation of initial antibiotic prescription to 24 hours, discouraging indiscriminate vancomycin use, and improving bedside communication and situational awareness regarding the infection diagnosis protocol.
Results:In total, 109 patients received the protocol; antibiotics were discontinued in 24 hours in 72 cases (66%). The most common reasons for continuing antibiotics beyond 24 hours were positive culture (n = 13) and provider preference (n = 13). A statistical process control analysis showed only a trend in monthly mean antibiotic utilization rate in the intervention period compared to the baseline period: 32.6% (SD, 6.1%) antibiotic utilization rate during the intervention period versus 36.6% (SD, 5.4%) during the baseline period (mean difference, 4%; 95% CI, −0.5% to −8.5%; P = .07). However, a special-cause variation represented a 26% reduction in mean monthly vancomycin use during the intervention period. In the patients who had antibiotics discontinued at 24 hours, delayed culture positivity was rare.
Conclusions:Implementation of a protocol limiting empiric antibiotic courses to 24 hours in clinically stable, standard-risk, pediatric CICU patients with negative cultures is feasible. This practice appears safe and may reduce harm by decreasing unnecessary antibiotic exposure.
Movements of loggerhead sea turtles (Caretta caretta) in the Gulf of California: integrating satellite telemetry and remotely sensed environmental variables
- Alejandra G. Sandoval-Lugo, T. Leticia Espinosa-Carreón, Jeffrey A. Seminoff, Catherine E. Hart, César P. Ley-Quiñónez, A. Alonso Aguirre, T. Todd Jones, Alan A. Zavala-Norzagaray
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- Journal:
- Journal of the Marine Biological Association of the United Kingdom / Volume 100 / Issue 5 / August 2020
- Published online by Cambridge University Press:
- 30 July 2020, pp. 817-824
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The loggerhead turtle (Caretta caretta) is a circumglobal species and is listed as vulnerable globally. The North Pacific population nests in Japan and migrates to the Central North Pacific and Pacific coast of North America to feed. In the Mexican Pacific, records of loggerhead presence are largely restricted to the Gulf of Ulloa along the Baja California Peninsula, where very high fisheries by-catch mortality has been reported. Records of loggerhead turtles within the Sea of Cortez also known as the Gulf of California (GC) exist; however, their ecology in this region is poorly understood. We used satellite tracking and an environmental variable analysis (chlorophyll-a (Chl-a) and sea surface temperature (SST)) to determine movements and habitat use of five juvenile loggerhead turtles ranging in straight carapace length from 62.7–68.3 cm (mean: 66.7 ± 2.3 cm). Satellite tracking durations ranged from 73–293 days (mean: 149 ± 62.5 days), transmissions per turtle from 14–1006 (mean: 462 ± 379.5 transmissions) and total travel distance from 1237–5222 km (mean: 3118 ± 1490.7 km). We used travel rate analyses to identify five foraging areas in the GC, which occurred mainly in waters from 10–80 m deep, with mean Chl-a concentrations ranging from 0.28–13.14 mg m−3 and SST ranging from 27.8–34.4°C. This is the first study to describe loggerhead movements in the Gulf of California and our data suggest that loggerhead foraging movements are performed in areas with eutrophic levels of Chl-a.
Increased Glyphosate Tolerance in ‘Aurora Gold’ Hard Fescue (Festuca longifolia)
- Stephen E. Hart, Jeffrey F. Derr, Darren W. Lycan, Crystal Rose-Fricker, William A. Meyer
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- Journal:
- Weed Technology / Volume 19 / Issue 3 / September 2005
- Published online by Cambridge University Press:
- 20 January 2017, pp. 640-646
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Studies were conducted in New Jersey and Virginia to evaluate the response of ‘Aurora Gold’ hard fescue, which had undergone five cycles of phenotypic recurrent selection for increased glyphosate tolerance, to direct applications of glyphosate. ‘Discovery’ hard fescue, which had not undergone recurrent selection, was also included in the study. Glyphosate treatments were initiated in early/mid-May and applied once, twice, or three times at 4- to 5-wk intervals at rates ranging from 0.1 to 1.6 kg ae/ha. Aurora Gold was more tolerant to glyphosate than Discovery in all experiments, indicating that recurrent selection was successful in increasing glyphosate tolerance in hard fescue. Single applications of glyphosate at rates ranging from 0.6 to 0.8 kg/ha could be applied to Aurora Gold with minimal injury or stand thinning (<20%), whereas multiple applications of glyphosate could be applied at rates ranging from 0.4 to 0.6 kg/ha. The use of Aurora Gold in areas planted to hard fescue, such as golf course roughs, vineyards, orchards, and landscapes, would allow the integration of direct glyphosate applications into an overall weed management program providing potential economic and environmental benefits.
Contributors
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- By Mitchell Aboulafia, Frederick Adams, Marilyn McCord Adams, Robert M. Adams, Laird Addis, James W. Allard, David Allison, William P. Alston, Karl Ameriks, C. Anthony Anderson, David Leech Anderson, Lanier Anderson, Roger Ariew, David Armstrong, Denis G. Arnold, E. J. Ashworth, Margaret Atherton, Robin Attfield, Bruce Aune, Edward Wilson Averill, Jody Azzouni, Kent Bach, Andrew Bailey, Lynne Rudder Baker, Thomas R. Baldwin, Jon Barwise, George Bealer, William Bechtel, Lawrence C. Becker, Mark A. Bedau, Ernst Behler, José A. Benardete, Ermanno Bencivenga, Jan Berg, Michael Bergmann, Robert L. Bernasconi, Sven Bernecker, Bernard Berofsky, Rod Bertolet, Charles J. Beyer, Christian Beyer, Joseph Bien, Joseph Bien, Peg Birmingham, Ivan Boh, James Bohman, Daniel Bonevac, Laurence BonJour, William J. Bouwsma, Raymond D. Bradley, Myles Brand, Richard B. Brandt, Michael E. Bratman, Stephen E. Braude, Daniel Breazeale, Angela Breitenbach, Jason Bridges, David O. Brink, Gordon G. Brittan, Justin Broackes, Dan W. Brock, Aaron Bronfman, Jeffrey E. Brower, Bartosz Brozek, Anthony Brueckner, Jeffrey Bub, Lara Buchak, Otavio Bueno, Ann E. Bumpus, Robert W. Burch, John Burgess, Arthur W. Burks, Panayot Butchvarov, Robert E. Butts, Marina Bykova, Patrick Byrne, David Carr, Noël Carroll, Edward S. Casey, Victor Caston, Victor Caston, Albert Casullo, Robert L. Causey, Alan K. L. Chan, Ruth Chang, Deen K. Chatterjee, Andrew Chignell, Roderick M. Chisholm, Kelly J. Clark, E. J. Coffman, Robin Collins, Brian P. Copenhaver, John Corcoran, John Cottingham, Roger Crisp, Frederick J. Crosson, Antonio S. Cua, Phillip D. Cummins, Martin Curd, Adam Cureton, Andrew Cutrofello, Stephen Darwall, Paul Sheldon Davies, Wayne A. Davis, Timothy Joseph Day, Claudio de Almeida, Mario De Caro, Mario De Caro, John Deigh, C. F. Delaney, Daniel C. Dennett, Michael R. DePaul, Michael Detlefsen, Daniel Trent Devereux, Philip E. Devine, John M. Dillon, Martin C. Dillon, Robert DiSalle, Mary Domski, Alan Donagan, Paul Draper, Fred Dretske, Mircea Dumitru, Wilhelm Dupré, Gerald Dworkin, John Earman, Ellery Eells, Catherine Z. Elgin, Berent Enç, Ronald P. Endicott, Edward Erwin, John Etchemendy, C. Stephen Evans, Susan L. Feagin, Solomon Feferman, Richard Feldman, Arthur Fine, Maurice A. Finocchiaro, William FitzPatrick, Richard E. Flathman, Gvozden Flego, Richard Foley, Graeme Forbes, Rainer Forst, Malcolm R. Forster, Daniel Fouke, Patrick Francken, Samuel Freeman, Elizabeth Fricker, Miranda Fricker, Michael Friedman, Michael Fuerstein, Richard A. Fumerton, Alan Gabbey, Pieranna Garavaso, Daniel Garber, Jorge L. A. Garcia, Robert K. Garcia, Don Garrett, Philip Gasper, Gerald Gaus, Berys Gaut, Bernard Gert, Roger F. Gibson, Cody Gilmore, Carl Ginet, Alan H. Goldman, Alvin I. Goldman, Alfonso Gömez-Lobo, Lenn E. Goodman, Robert M. Gordon, Stefan Gosepath, Jorge J. E. Gracia, Daniel W. Graham, George A. Graham, Peter J. Graham, Richard E. Grandy, I. Grattan-Guinness, John Greco, Philip T. Grier, Nicholas Griffin, Nicholas Griffin, David A. Griffiths, Paul J. Griffiths, Stephen R. Grimm, Charles L. Griswold, Charles B. Guignon, Pete A. Y. Gunter, Dimitri Gutas, Gary Gutting, Paul Guyer, Kwame Gyekye, Oscar A. Haac, Raul Hakli, Raul Hakli, Michael Hallett, Edward C. Halper, Jean Hampton, R. James Hankinson, K. R. Hanley, Russell Hardin, Robert M. Harnish, William Harper, David Harrah, Kevin Hart, Ali Hasan, William Hasker, John Haugeland, Roger Hausheer, William Heald, Peter Heath, Richard Heck, John F. Heil, Vincent F. Hendricks, Stephen Hetherington, Francis Heylighen, Kathleen Marie Higgins, Risto Hilpinen, Harold T. Hodes, Joshua Hoffman, Alan Holland, Robert L. Holmes, Richard Holton, Brad W. Hooker, Terence E. Horgan, Tamara Horowitz, Paul Horwich, Vittorio Hösle, Paul Hoβfeld, Daniel Howard-Snyder, Frances Howard-Snyder, Anne Hudson, Deal W. Hudson, Carl A. Huffman, David L. Hull, Patricia Huntington, Thomas Hurka, Paul Hurley, Rosalind Hursthouse, Guillermo Hurtado, Ronald E. Hustwit, Sarah Hutton, Jonathan Jenkins Ichikawa, Harry A. Ide, David Ingram, Philip J. Ivanhoe, Alfred L. Ivry, Frank Jackson, Dale Jacquette, Joseph Jedwab, Richard Jeffrey, David Alan Johnson, Edward Johnson, Mark D. Jordan, Richard Joyce, Hwa Yol Jung, Robert Hillary Kane, Tomis Kapitan, Jacquelyn Ann K. Kegley, James A. Keller, Ralph Kennedy, Sergei Khoruzhii, Jaegwon Kim, Yersu Kim, Nathan L. King, Patricia Kitcher, Peter D. Klein, E. D. Klemke, Virginia Klenk, George L. Kline, Christian Klotz, Simo Knuuttila, Joseph J. Kockelmans, Konstantin Kolenda, Sebastian Tomasz Kołodziejczyk, Isaac Kramnick, Richard Kraut, Fred Kroon, Manfred Kuehn, Steven T. Kuhn, Henry E. Kyburg, John Lachs, Jennifer Lackey, Stephen E. Lahey, Andrea Lavazza, Thomas H. Leahey, Joo Heung Lee, Keith Lehrer, Dorothy Leland, Noah M. Lemos, Ernest LePore, Sarah-Jane Leslie, Isaac Levi, Andrew Levine, Alan E. Lewis, Daniel E. Little, Shu-hsien Liu, Shu-hsien Liu, Alan K. L. Chan, Brian Loar, Lawrence B. Lombard, John Longeway, Dominic McIver Lopes, Michael J. Loux, E. J. Lowe, Steven Luper, Eugene C. Luschei, William G. Lycan, David Lyons, David Macarthur, Danielle Macbeth, Scott MacDonald, Jacob L. Mackey, Louis H. Mackey, Penelope Mackie, Edward H. Madden, Penelope Maddy, G. B. Madison, Bernd Magnus, Pekka Mäkelä, Rudolf A. Makkreel, David Manley, William E. Mann (W.E.M.), Vladimir Marchenkov, Peter Markie, Jean-Pierre Marquis, Ausonio Marras, Mike W. Martin, A. P. Martinich, William L. McBride, David McCabe, Storrs McCall, Hugh J. McCann, Robert N. McCauley, John J. McDermott, Sarah McGrath, Ralph McInerny, Daniel J. McKaughan, Thomas McKay, Michael McKinsey, Brian P. McLaughlin, Ernan McMullin, Anthonie Meijers, Jack W. Meiland, William Jason Melanson, Alfred R. Mele, Joseph R. Mendola, Christopher Menzel, Michael J. Meyer, Christian B. Miller, David W. Miller, Peter Millican, Robert N. Minor, Phillip Mitsis, James A. Montmarquet, Michael S. Moore, Tim Moore, Benjamin Morison, Donald R. Morrison, Stephen J. Morse, Paul K. Moser, Alexander P. D. Mourelatos, Ian Mueller, James Bernard Murphy, Mark C. Murphy, Steven Nadler, Jan Narveson, Alan Nelson, Jerome Neu, Samuel Newlands, Kai Nielsen, Ilkka Niiniluoto, Carlos G. Noreña, Calvin G. Normore, David Fate Norton, Nikolaj Nottelmann, Donald Nute, David S. Oderberg, Steve Odin, Michael O’Rourke, Willard G. Oxtoby, Heinz Paetzold, George S. Pappas, Anthony J. Parel, Lydia Patton, R. P. Peerenboom, Francis Jeffry Pelletier, Adriaan T. Peperzak, Derk Pereboom, Jaroslav Peregrin, Glen Pettigrove, Philip Pettit, Edmund L. Pincoffs, Andrew Pinsent, Robert B. Pippin, Alvin Plantinga, Louis P. Pojman, Richard H. Popkin, John F. Post, Carl J. Posy, William J. Prior, Richard Purtill, Michael Quante, Philip L. Quinn, Philip L. Quinn, Elizabeth S. Radcliffe, Diana Raffman, Gerard Raulet, Stephen L. Read, Andrews Reath, Andrew Reisner, Nicholas Rescher, Henry S. Richardson, Robert C. Richardson, Thomas Ricketts, Wayne D. Riggs, Mark Roberts, Robert C. Roberts, Luke Robinson, Alexander Rosenberg, Gary Rosenkranz, Bernice Glatzer Rosenthal, Adina L. Roskies, William L. Rowe, T. M. Rudavsky, Michael Ruse, Bruce Russell, Lilly-Marlene Russow, Dan Ryder, R. M. Sainsbury, Joseph Salerno, Nathan Salmon, Wesley C. Salmon, Constantine Sandis, David H. Sanford, Marco Santambrogio, David Sapire, Ruth A. Saunders, Geoffrey Sayre-McCord, Charles Sayward, James P. Scanlan, Richard Schacht, Tamar Schapiro, Frederick F. Schmitt, Jerome B. Schneewind, Calvin O. Schrag, Alan D. Schrift, George F. Schumm, Jean-Loup Seban, David N. Sedley, Kenneth Seeskin, Krister Segerberg, Charlene Haddock Seigfried, Dennis M. Senchuk, James F. Sennett, William Lad Sessions, Stewart Shapiro, Tommie Shelby, Donald W. Sherburne, Christopher Shields, Roger A. Shiner, Sydney Shoemaker, Robert K. Shope, Kwong-loi Shun, Wilfried Sieg, A. John Simmons, Robert L. Simon, Marcus G. Singer, Georgette Sinkler, Walter Sinnott-Armstrong, Matti T. Sintonen, Lawrence Sklar, Brian Skyrms, Robert C. Sleigh, Michael Anthony Slote, Hans Sluga, Barry Smith, Michael Smith, Robin Smith, Robert Sokolowski, Robert C. Solomon, Marta Soniewicka, Philip Soper, Ernest Sosa, Nicholas Southwood, Paul Vincent Spade, T. L. S. Sprigge, Eric O. Springsted, George J. Stack, Rebecca Stangl, Jason Stanley, Florian Steinberger, Sören Stenlund, Christopher Stephens, James P. Sterba, Josef Stern, Matthias Steup, M. A. Stewart, Leopold Stubenberg, Edith Dudley Sulla, Frederick Suppe, Jere Paul Surber, David George Sussman, Sigrún Svavarsdóttir, Zeno G. Swijtink, Richard Swinburne, Charles C. Taliaferro, Robert B. Talisse, John Tasioulas, Paul Teller, Larry S. Temkin, Mark Textor, H. S. Thayer, Peter Thielke, Alan Thomas, Amie L. Thomasson, Katherine Thomson-Jones, Joshua C. Thurow, Vzalerie Tiberius, Terrence N. Tice, Paul Tidman, Mark C. Timmons, William Tolhurst, James E. Tomberlin, Rosemarie Tong, Lawrence Torcello, Kelly Trogdon, J. D. Trout, Robert E. Tully, Raimo Tuomela, John Turri, Martin M. Tweedale, Thomas Uebel, Jennifer Uleman, James Van Cleve, Harry van der Linden, Peter van Inwagen, Bryan W. Van Norden, René van Woudenberg, Donald Phillip Verene, Samantha Vice, Thomas Vinci, Donald Wayne Viney, Barbara Von Eckardt, Peter B. M. Vranas, Steven J. Wagner, William J. Wainwright, Paul E. Walker, Robert E. Wall, Craig Walton, Douglas Walton, Eric Watkins, Richard A. Watson, Michael V. Wedin, Rudolph H. Weingartner, Paul Weirich, Paul J. Weithman, Carl Wellman, Howard Wettstein, Samuel C. Wheeler, Stephen A. White, Jennifer Whiting, Edward R. Wierenga, Michael Williams, Fred Wilson, W. Kent Wilson, Kenneth P. Winkler, John F. Wippel, Jan Woleński, Allan B. Wolter, Nicholas P. Wolterstorff, Rega Wood, W. Jay Wood, Paul Woodruff, Alison Wylie, Gideon Yaffe, Takashi Yagisawa, Yutaka Yamamoto, Keith E. Yandell, Xiaomei Yang, Dean Zimmerman, Günter Zoller, Catherine Zuckert, Michael Zuckert, Jack A. Zupko (J.A.Z.)
- Edited by Robert Audi, University of Notre Dame, Indiana
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- Book:
- The Cambridge Dictionary of Philosophy
- Published online:
- 05 August 2015
- Print publication:
- 27 April 2015, pp ix-xxx
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Oesophageal perforation in a neonate during transoesophageal echocardiography for cardiac surgery
- Jeffrey W. Miller, Catherine K. Hart, Christopher J. Statile
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- Journal:
- Cardiology in the Young / Volume 25 / Issue 5 / June 2015
- Published online by Cambridge University Press:
- 09 September 2014, pp. 1015-1018
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Oesophageal perforation is a rarely reported complication of transoesophageal echocardiography in infants. This case involves a 3.1-kg neonate with Trisomy 21, atrioventricular septal defect, and hypoplastic aortic arch undergoing aortic arch advancement and pulmonary artery banding. A paediatric transoesophageal echocardiography probe was placed intraoperatively causing a contained false passage from the oesophagus below the cricopharyngeus muscle with extension into the left posterior mediastinum. The perforation healed within 2 weeks without permanent sequelae after conservative medical management.
When Small States Make Big Leaps: Institutional Innovation and High-Tech Competition in Western Europe. By Darius Ornston. Ithaca, NY: Cornell University Press, 2012. 240p. $39.95.
- Jeffrey A. Hart
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- Journal:
- Perspectives on Politics / Volume 12 / Issue 2 / June 2014
- Published online by Cambridge University Press:
- 14 July 2014, pp. 548-549
- Print publication:
- June 2014
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- By Nazia M. Alam, Enrico Alleva, Hiroyuki Arakawa, Robert H. Benno, Fred G. Biddle, D. Caroline Blanchard, Robert J. Blanchard, Richard J. Bodnar, John D. Boughter, Igor Branchi, Richard E. Brown, Abel Bult-Ito, Jonathan M. Cachat, Peter R. Canavello, Francesca Cirulli, Giovanni Colacicco, John C. Crabbe, Jacqueline N. Crawley, Wim E. Crusio, Sietse F. de Boer, Ekrem Dere, Brenda A. Eales, Robert T. Gerlai, Howard K. Gershenfeld, Thomas J. Gould, Martin E. Hahn, Peter C. Hart, Andrew Holmes, Joseph P. Huston, Allan V. Kalueff, Benjamin Kest, Robert Lalonde, Sarah R. Lewis-Levy, Hans-Peter Lipp, Sheree F. Logue, Stephen C. Maxson, Jeffrey S. Mogil, Douglas A. Monks, Dennis L. Murphy, Lee Niel, Timothy P. O’Leary, Susanna Pietropaolo, Peter K.D. Pilz, Claudia F. Plappert, Bernard Possidente, Glen T. Prusky, Laura Ricceri, Heather Schellinck, Herbert Schwegler, Burton Slotnick, Frans Sluyter, Shad B. Smith, Catherine Strazielle, Douglas Wahlsten, Hans Welzl, James F. Willott, David P. Wolfer, Armin Zlomuzica
- Edited by Wim E. Crusio, Université de Bordeaux, Frans Sluyter, Robert T. Gerlai, University of Toronto, Susanna Pietropaolo, Université de Bordeaux
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- Book:
- Behavioral Genetics of the Mouse
- Published online:
- 05 May 2013
- Print publication:
- 25 April 2013, pp ix-xii
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Contributors
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- By James Ahn, Eric L. Anderson, Annette L. Beautrais, Dennis Beedle, Jon S. Berlin, Benjamin L. Bregman, Peter Brown, Suzie Bruch, Jonathan Busko, Stuart Buttlaire, Laurie Byrne, Gerald Carroll, Valerie A. Carroll, Margaret Cashman, Joseph R. Check, Lara G. Chepenik, Robert N. Cuyler, Preeti Dalawari, Suzanne Dooley-Hash, William R. Dubin, Mila L. Felder, Avrim B. Fishkind, Reginald I. Gaylord, Rachel Lipson Glick, Travis Grace, Clare Gray, Anita Hart, Ross A. Heller, Amanda E. Horn, David S. Howes, David C. Hsu, Andy Jagoda, Margaret Judd, John Kahler, Daryl Knox, Gregory Luke Larkin, Patricia Lee, Jerrold B. Leikin, Eddie Markul, Marc L. Martel, J. D. McCourt, MaryLynn McGuire Clarke, Mark Newman, Anthony T. Ng, Barbara Nightengale, Kimberly Nordstrom, Jagoda Pasic, Jennifer Peltzer-Jones, Marcia A. Perry, Larry Phillips, Paul Porter, Seth Powsner, Michael S. Pulia, Erin Rapp, Divy Ravindranath, Janet S. Richmond, Silvana Riggio, Harvey L. Ruben, Derek J. Robinson, Douglas A. Rund, Omeed Saghafi, Alicia N. Sanders, Jeffrey Sankoff, Lorin M. Scher, Louis Scrattish, Richard D. Shih, Maureen Slade, Susan Stefan, Victor G. Stiebel, Deborah Taber, Vaishal Tolia, Gary M. Vilke, Alvin Wang, Michael A. Ward, Joseph Weber, Michael P. Wilson, James L. Young, Scott L. Zeller
- Edited by Leslie S. Zun
- Edited in association with Lara G. Chepenik, Mary Nan S. Mallory
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- Book:
- Behavioral Emergencies for the Emergency Physician
- Published online:
- 05 April 2013
- Print publication:
- 21 March 2013, pp viii-xii
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A Bootstrap Test for Positive Definiteness of Income Effect Matrices
- Wolfgang Härdle, Jeffrey D. Hart
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- Journal:
- Econometric Theory / Volume 8 / Issue 2 / June 1992
- Published online by Cambridge University Press:
- 18 October 2010, pp. 276-292
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Positive definiteness of income effect matrices provides a sufficient condition for the law of demand to hold. Given cross section household expenditure data, empirical evidence for the law of demand can be obtained by estimating such matrices. Härdle, Hildenbrand, and Jerison used the bootstrap method to simulate the distribution of the smallest eigenvalue of random matrices and to test their positive definiteness. Here, theoretical aspects of this bootstrap test of positive definiteness are considered. The asymptotic distribution of the smallest eigenvalue , of the matrix estimate is obtained. This theory applies generally to symmetric, asymptotically normal random matrices. A bootstrap approximation to the distribution of is shown to converge in probability to the asymptotic distribution of . The bootstrap test is illustrated using British family expenditure survey data.
Burke and Radical Freedom
- Jeffrey Hart
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- The Review of Politics / Volume 29 / Issue 2 / April 1967
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- 05 August 2009, pp. 221-238
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As everyone knows, an enormous revival of interest in Edmund Burke has taken place during the past twenty years or so, the period, roughly, since the end of the Second World War. Scholars, to be sure, have always been interested in him, and he was widely admired for his style, and by some for his “practical wisdom,” during the nineteenth century. But the point is that in our time he has come to be read not merely as one among a large number of other important figures in the history of political thought, but as a thinker of intense, of special, contemporary relevance. Burke is our contemporary, he is an issue, in a way that Locke is not, and Leibniz is not, and even Mill is not. Burke has not receded into what Lovejoy called the pathos of time, by which he meant that benign and even tender feeling we have for thought that is now completely, forever, a part of the past — and so neither defines us nor menaces us.
Digital Formations: IT and New Architectures in the Global Realm
- Jeffrey A. Hart
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- Journal:
- Perspectives on Politics / Volume 5 / Issue 3 / September 2007
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- 16 August 2007, pp. 675-676
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- September 2007
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Digital Formations: IT and New Architectures in the Global Realm. Edited by Robert Latham and Saskia Sassen. Princeton: Princeton University Press, 2005. 367p. $65.00 cloth, $27.95 paper.
This is an interesting collection of essays about what the editors call “digital formations.” A social formation is something in society that is emerging without a single founding event, in its early stages of development, and tending toward a variable structure and nature (p. 9). Despite this, “you should be able to identify a coherent configuration of organization, space, and interaction” (p. 10). Several of the social formations studied by the authors in this volume are only partly digital: that is, they combine digital and nondigital elements. They are all, however, subject to “digitization,” which involves the “rendering of facets of social and political life in a digital form” (p. 16). One important reason for studying digital formations is that some are potentially “destabilizing of existing hierarchies of scale and nested hierarchies” (p. 19), while others reinforce them. An example of the former is the open-source software movement (as chronicled here by Steve Weber); an example of the latter is what Dieter Ernst in his chapter calls the “global flagship networks” created by large multinational corporations.
Information Please: Culture and Politics in the Age of Digital Machines
- Jeffrey A. Hart
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- Journal:
- Perspectives on Politics / Volume 5 / Issue 2 / June 2007
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- 14 May 2007, pp. 412-413
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- June 2007
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Information Please: Culture and Politics in the Age of Digital Machines. By Mark Poster. Durham, NC: Duke University Press, 2006. 393p. $79.95 Cloth, $22.95 paper.
In this book, Mark Poster attempts to provide a philosophical framework for understanding the significance of the rise of computers, the Internet, and the other digital technologies. His argument is that the diffusion of these new technologies results in “complex couplings of humans and machines” (p. 9) that call into question some of the central ideas of our time. The discussion starts with postcolonial theory and then moves on to recent theories of empire, citizenship, identity, ethics, psychoanalysis, intellectual property rights, everyday life, and consumer culture. It is an ambitious work and difficult to read in passages, but the effort is worth it.
4 - HDTV in Japan
- Jeffrey A. Hart, Indiana University
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- Book:
- Technology, Television, and Competition
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- 22 September 2009
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- 05 February 2004, pp 84-99
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Summary
The global story of HDTV begins with the decision of Japan's national public broadcaster, NHK (Nippon Hoso Kyokai), to begin research on next-generation television technologies. Prior to and during the 1964 Tokyo Olympics, there was a major jump in TV sales in Japan. The dissatisfaction of engineers at NHK's Technical Laboratories with the quality of television coverage of the Tokyo Olympics and the improved ability of NHK to finance television research were the two main reasons why NHK Laboratories began to do research on advanced television technologies in 1964. From that point on, NHK was the key actor pushing for HDTV in Japan. NHK's leadership depended critically on its control over the core technologies for Japan's version of HDTV. Because NHK was enjoined by law not to engage directly in manufacturing activities, it began in 1970 to assemble a coalition of manufacturers to support its work on HDTV technologies. NHK then used its coalition to win support for national HDTV standards. It did not succeed in winning sufficient support for its approach to HDTV outside of Japan, however, for reasons to be explored in later chapters.
NHK's research on MUSE/Hi-Vision
Two NHK laboratories were established in 1930: one for broadcasting issues (including viewer surveys) and the other for technical issues. NHK Science and Technical Research Laboratories (NHK Labs for short) were supposed to investigate scientific and technical issues with the potential to have long-term effects on broadcasting.
7 - Digital television in the United States
- Jeffrey A. Hart, Indiana University
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- Book:
- Technology, Television, and Competition
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- 22 September 2009
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- 05 February 2004, pp 150-180
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Summary
Introduction
Chapter 5 provided a history of the US debate over HDTV standards up to the decision on 23 May 1993 to merge the competing electronics firms into a “grand alliance” for a digital high-definition television system. This chapter starts from that point and brings the history up to and bit beyond 3 April 1997, when the Federal Communications Commission formally adopted a standard for digital television (DTV) in the United States. During this period, there was a change in the attitude of the members of the National Association of Broadcasters toward HDTV: they began to see it as an answer to the problem of declining audience shares. There were also continuous but only partially successful lobbying efforts on the part of major computer firms to have the HDTV standards modified to accommodate their perceived interests. The most important change was brought about by the victory of William Jefferson Clinton in the 1992 presidential elections. Clinton's Vice President, Albert Gore, was a strong exponent of governmental support for the building of an “Information Superhighway.” Clinton, Gore, and their appointed head of the Federal Communications Commission, Reed Hundt, came to believe in the idea of “digital convergence” and had strong views on the role that television should play in that larger project.
Interlace vs. progressive-scan: round one
There was furious bargaining within the grand alliance prior to the announcement of its formation on 24 May 1993 to reconcile the differences in the four digital systems.
1 - Introduction
- Jeffrey A. Hart, Indiana University
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- Book:
- Technology, Television, and Competition
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- 22 September 2009
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- 05 February 2004, pp 1-16
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Summary
We live in the midst of a transition to an age of digital technologies. As in previous large technological transitions, many established interests are threatened and many new ones have arisen. The semiconductor, computer, telecommunications, and software industries (the core information technology industries) have become the political voice of these new interests. Just as innovators like Andrew Carnegie came to symbolize the iron and steel industry in the nineteenth century, and Henry Ford the automobile industry in the early twentieth century, industry figures like Steve Jobs of Apple, Andy Grove of Intel, and Bill Gates of Microsoft represented the spirit of the information age. These new icons of innovation lobbied for policies that were sometimes inconsistent with those favored by older industries, such as textiles, steel, chemicals, and motor vehicles.
Joseph Schumpeter called this displacement resulting from technological change of old interests by new ones “creative destruction.” Older industries, according to Schumpeter, would organize politically to block the institutional changes that accompanied the introduction of new technologies. If these changes were delayed, then a shift in the distribution of political power could also be delayed. But eventually, competitive pressures would overcome the resistance to institutional change and a new distribution of power would emerge to force the old interests to come to terms with the new.
Something of this sort occurred in the debates over high definition television (HDTV) and digital television (DTV) that began in the early 1980s.
6 - HDTV in Europe
- Jeffrey A. Hart, Indiana University
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- Book:
- Technology, Television, and Competition
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- 22 September 2009
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- 05 February 2004, pp 118-149
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Summary
Introduction
The international HDTV standard-setting effort became especially politicized due to competitive imbalances between the three major poles of industrial activity: Japan, Europe, and the United States. The significance of these imbalances was magnified by certain structural weaknesses of the European Commission, which led to an especially complicated interaction among the regions, and which ultimately defeated hopes for a unified world standard.
After NHK initially gained the upper hand in Japanese policy circles it tried to consolidate its position through ties to American users of the new technology whose behavior would affect the attractiveness of the MUSE/Hi-Vision standard internationally. NHK then tried to use that transnational coalition to globalize its standard in the CCIR, which would have further strengthened its position at home. Compromises made in order to secure American collaboration backfired, however, as they alerted key European consumer electronics firms and the European Commission to the potential threat to European competitiveness. As the guardian of the “Community interest,” the Commission played up the potential harmful consequences of global adoption of a Japanese standard for the market position of European electronics and audiovisual producers. The Commission then forged a blocking coalition with producers and PTTs that enabled Europe to forestall a choice on global standards. The European delay activated American interests which had hitherto been passive about the issue, sparking debate in America with respect to the technology's consumer and strategic implications and rekindling a competitive standards-setting process in the US.
Acknowledgments
- Jeffrey A. Hart, Indiana University
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- Technology, Television, and Competition
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- 22 September 2009
- Print publication:
- 05 February 2004, pp x-x
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